Alteration of regional cerebral blood flow to thyr...[Eur J Paediatr Neurol. 2006] - PubMed Result

Alteration of regional cerebral blood flow to thyr...[Eur J Paediatr Neurol. 2006] - PubMed Result: "Links Alteration of regional cerebral blood flow to thyrotropin-releasing hormone therapy in acute encephalitis and encephalopathy during childhood. Yoshinari S, Hamano S, Tanaka M, Minamitani M. Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan. a2004341@pref.saitama.lg.jp BACKGROUND: Thyrotropin-releasing hormone (TRH) is now used as a therapeutic agent for various neurological disorders. Animal study has shown that TRH was attributable to increased cerebral blood flow (CBF). AIMS: There have been occasional reports that TRH therapy was effective for improving symptoms of persistent disturbance of consciousness after acute encephalitis or encephalopathy during childhood. To determine whether TRH has an effect on increasing CBF to patients who have consciousness disturbance caused by acute encephalitis or encephalopathy, and to determine the optimal method of administration. METHODS: Sixteen patients aged 0.7-10.9 years (mean age, 3.2+/-3.1 years) who presented with persistent disturbance of consciousness resulting from acute encephalitis or encephalopathy and were treated with TRH. Regional CBF (rCBF) was measured by single photon emission computed tomography before"